|
KMID : 1134820220510101007
|
|
Journal of the Korean Society of Food Science and Nutrition
2022 Volume.51 No. 10 p.1007 ~ p.1014
|
|
|
Inhibitory Effects of the Ethanol Extract of Viscum album var. coloratum on Benign Prostatic Hyperplasia
|
|
Kim So-Hyuk
Son Hyung-Gu
Lee Jeong-Yoon
Lee Yoo-Hyun
|
|
|
Abstract
|
|
|
|
This study assessed the effects of mistletoe extract (VA30E) on benign prostatic hyperplasia (BPH) using in vitro and in vivo models. The in vitro study was performed in BPH-1 cells, wherein VA30E treatment at concentrations of 200 μg/mL decreased cell proliferation by 98.97%. VA30E dose-dependently reduced mRNA expression of the androgen receptors. The in vivo study was undertaken with seven-week-old male Sprague-Dawley rats. Surgical castration was conducted to exclude endogenous testosterone (T) and the rats were divided into five groups; control, BPH, VA30E-50 [50 mg/kg of body weight (BW)/d], VA30E-150 (150 mg/kg of BW/d) and saw palmetto (positive control, 100 mg/kg of BW/d). The prostate size of the rats showed a decrease with the administration of VA30E compared to the BPH group. The prostate weight ratio (BW to prostate weight) also decreased in a dose-dependent manner by up to 13.04% in the VA30E-150 group (P<0.05). In addition, T and dihydrotestosterone levels were significantly reduced by 46.01% and 22.26%, respectively, in the VA30E-150 group compared to the BPH group. The 5-alpha reductase 2 levels were also significantly decreased in a dose-dependent manner by the administration of VA30E. Taken together, these results suggest that VA30E could be used as a functional ingredient in the treatment of BPH symptoms.
|
|
|
KEYWORD
|
|
|
5α-reductase, androgen receptor, benign prostatic hyperplasia, dihydrotestosterone, Viscum album var. coloratum
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|